5,000+ Tech Workers Laid Off This Week. It's Just The Beginning. | E2286

Watch on YouTube ↗  |  May 09, 2026 at 00:46  |  1:11:25  |  This Week in Startups
Speakers

Summary

The episode covers on-prem AI hardware for regulated industries (Go Abacus), decentralized identity verification on BitTensor (Yanez), and recent tech layoffs at Cloudflare, Coinbase, and Block. Jason Calacanis highlights Block's AI-driven earnings beat as a validation of AI efficiency, and discusses investment opportunities in BitTensor's TAO token. The show ends with a debate on federalism and AI regulation.

  • David Moscatelli presents Go Abacus, an on-prem AI hardware appliance for regulated industries with 1,600 pre-orders.
  • Jose Caldera introduces Yanez, a BitTensor subnet (54) for decentralized identity and proof-of-human verification.
  • Cloudflare and Coinbase announce significant layoffs as part of AI-driven restructuring.
  • Block reports a strong earnings beat after cutting 40% of staff and achieving 100% AI tool adoption.
  • Jason Calacanis is bullish on BitTensor (TAO) as a small-cap crypto opportunity with 128 competing subnets.
  • Jason avoids Anthropic at its current $900B valuation, expecting cheaper entry post-IPO.
  • The hosts discuss the rise of AI-first startups and the shift toward smaller, independent contractor-led teams.
  • A debate on federalism vs. federal AI regulation closes the show, with Jason advocating for state-level control.
Trade Ideas
Jason Calacanis Angel Investor / Founder, LAUNCH 45:18
TAO is a small-cap crypto opportunity
BitTensor (TAO) has a market cap of $910M with 128 subnets competing. Jason considers it a small-cap opportunity similar to a startup accelerator, and he has invested in TAO. He sees upside from subnet growth and permissionless innovation.
Jason Calacanis Angel Investor / Founder, LAUNCH 56:01
SQ AI-driven earnings beat confirms thesis
Block (SQ) is benefiting from AI-driven efficiency: 100% of employees use AI tools, leading to an earnings beat and raised guidance. EPS grew 26% YoY and is expected to grow ~50% next year. Jason sees this as a validation of AI's impact on profitability.
Up Next

This This Week in Startups video, published May 09, 2026, features Jason Calacanis discussing TAO, XYZ. 2 trade ideas extracted by AI with direction and confidence scoring.

Speakers: Jason Calacanis  · Tickers: TAO, XYZ