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Premarket Alpha Post-Market Alpha

Daily Alpha · Substack

The public material pointed to vertical integration in AI hardware and a separate long-duration thesis in generative biology.

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Themes on this desk

Custom inference silicon

SemiAnalysis highlighted OpenAI's announced Jalapeño inference chip and the coming benchmark test against Nvidia systems.

Generative biology

Outlier Capital framed AI drug discovery as a potential change in pharmaceutical development economics.

Substack - SemiAnalysis

OpenAI announces Jalapeño inference ASIC

OpenAI has officially announced 'Jalapeño,' a custom-designed inference chip, following successful tapeout and internal lab validation.

Signals a strategic shift toward vertical integration in AI hardware to optimize inference costs and throughput, potentially challenging Nvidia's dominance in the inference market.

Watch Performance benchmarks and deployment timelines compared to Nvidia's Blackwell and Rubin architectures.

Source →
public excerpt 440 chars read
Substack - Outlier Capital

AI drug discovery platforms identified as high-conviction investment

AI-driven drug discovery platforms are positioned as a high-conviction sector with the potential to fundamentally rewrite the economics of pharmaceutical development.

Suggests a shift in biotech valuation models toward companies leveraging generative biology to reduce R&D costs and timelines.

Watch Clinical trial success rates and partnership announcements for AI-native biotech firms.

Source →
public excerpt 285 chars read