[Currently reactors are only using 3-5% of uraniums energy potential](https://www.ornl.gov/news/advancing-nuclear-fuel-design-safer-more-efficient-reactors). Theoretically - with perfect efficiency - 95% of uranium currently in demand could dissapear.
Even factoring in growing energy demand, that is quite stark. They are actively advancing on this and there is still lots of room for growth, as nuclear research has been underappreciated for decades.