Andrew Huberman: Peptides, Sleep Tech, and the End of Obesity

Watch on YouTube ↗  |  March 09, 2026 at 15:08  |  50:51  |  a16z
Speakers
Daisy Wolf — Partner, a16z
Andrew Huberman — Professor of Neurobiology and Ophthalmology, Stanford University; Host, Huberman Lab

Summary

Daisy Wolf interviews Dr. Andrew Huberman about the consumer health revolution, the rapid adoption of GLP-1 drugs and non-GLP peptides, and the future of sleep, biosensing, and neurotechnology. Huberman shares bullish views on obesity drugs, peptide therapeutics, mRNA cancer vaccines, and non-invasive neuromodulation, while cautioning on stimulant overuse and risky peptides. The conversation highlights emerging investment themes in health tech and biotech.

  • Pandemic accelerated a self-directed consumer health movement.
  • GLP-1 adoption is rising and could help eradicate obesity.
  • Eli Lilly's retatrutide shows strong weight loss and muscle sparing.
  • Non-GLP peptides are going mainstream despite safety concerns.
  • Sleep technology and real-time biosensing are emerging themes.
  • AI diagnostics and non-invasive neuromodulation are promising.
  • Huberman is bullish on mRNA cancer vaccines and magnesium supplements.
  • Longevity research on plasma rejuvenation is an early theme.
Ideas
Daisy Wolf Partner, a16z 1:19
Consumer health spending is rising.
The pandemic and the collision of fitness with mainstream medicine have sparked a consumer health revolution. People are now much more interested in spending on their own health, not just vanity drugs like Propecia or Viagra.
Andrew Huberman Professor of Neurobiology and Ophthalmology, Stanford University; Host, Huberman Lab 7:42
mRNA cancer vaccines are transformative.
mRNA vaccines for cancer are a transformative, incredible life-saving technology. Funding for cancer mRNA was not cut, only for respiratory illnesses, making the cancer applications a key opportunity.
Andrew Huberman Professor of Neurobiology and Ophthalmology, Stanford University; Host, Huberman Lab 13:05
GLP-1 adoption to rise broadly.
Nearly one in seven Americans take a GLP-1 and 20% have tried them. Adoption will rise, possibly over half of Americans, especially those with family obesity, often at lower doses via compounding/gray market. In theory, obesity could be eradicated.
Andrew Huberman Professor of Neurobiology and Ophthalmology, Stanford University; Host, Huberman Lab 13:14
Lilly's retatrutide drives obesity drug growth.
Retatrutide, Lilly's GLP-3, showed phase 3 weight loss up to a third of body weight with some muscle sparing and fewer side effects. It is already being sold by compounding and gray market sources, and Lilly is working to control compounding.
Andrew Huberman Professor of Neurobiology and Ophthalmology, Stanford University; Host, Huberman Lab 27:49
Sunosi to gain popularity for focus.
Sunosi is FDA-approved for excessive daytime sleepiness and did well in an ADHD trial. It has a gentler arc of alertness and focus because it also hits serotonin slightly, unlike pure stimulants. It will become far more popular soon.
Andrew Huberman Professor of Neurobiology and Ophthalmology, Stanford University; Host, Huberman Lab 31:05
Sleep tech will be a big market.
We will shift from reading to writing our biology around sleep. Technologies like cooling the core through palms/feet, eye-moving sleep masks, 10,000 lux light masks, and warming the body before waking are straightforward to build and will be a big market.
Andrew Huberman Professor of Neurobiology and Ophthalmology, Stanford University; Host, Huberman Lab 31:13
Multi-biomarker sensors including cortisol coming.
Real-time cortisol sensing would be very valuable; a big morning cortisol pulse and afternoon trough are critical for health. Currently only continuous glucose monitors exist, but multi-biomarker sensors that can measure cortisol and other analytes are being developed.
Andrew Huberman Professor of Neurobiology and Ophthalmology, Stanford University; Host, Huberman Lab 31:13
Multi-biomarker sensors including cortisol coming.
Real-time cortisol sensing would be very valuable; a big morning cortisol pulse and afternoon trough are critical for health. Currently only continuous glucose monitors exist, but multi-biomarker sensors that can measure cortisol and other analytes are being developed.
Andrew Huberman Professor of Neurobiology and Ophthalmology, Stanford University; Host, Huberman Lab 34:01
Peptide therapeutics going mainstream.
Non-GLP peptides like BPC-157, Pinealon, growth hormone secretagogues (tesamorelin, ipamorelin, sermorelin, MK-677), and melanotan are already widely used through compounding, gray, and black markets. The horse is out of the stable; in five years, people will take peptide cocktails for sleep, dopamine, micronutrients, and Alzheimer's protection, making peptide therapeutics mainstream.
Andrew Huberman Professor of Neurobiology and Ophthalmology, Stanford University; Host, Huberman Lab 34:44
Magnesium supplements to become mainstream.
Magnesium is the next wave of accepted supplements. It feels safe enough for most people, is low cost, and most everyone will be taking it.
Daisy Wolf Partner, a16z 35:02
AI diagnostics will transform healthcare.
On the read side, AI is already an incredible doctor; health information exchanges will feed all health records, wearables, blood tests, and imaging into models in real time to diagnose issues before symptoms appear. Wearables already detected COVID before symptoms.
Andrew Huberman Professor of Neurobiology and Ophthalmology, Stanford University; Host, Huberman Lab 39:46
Invest in non-invasive neuromodulation.
The holy grail is dialing in cognitive states. Non-invasive technologies that modify brain state through the eyes, ears, and superficial nerves are phenomenal. If he were to personally invest in companies, he would focus on this body area.
Andrew Huberman Professor of Neurobiology and Ophthalmology, Stanford University; Host, Huberman Lab 42:53
Plasma rejuvenation is promising longevity tech.
Tony Wyss-Coray's work on factors in young and exercised blood that rejuvenate the brain and body is exciting. He would bank his own exercised blood for future infusions, as blood infusions of exercised blood are beneficial.
Up Next

This a16z video, published March 09, 2026, features Daisy Wolf, Andrew Huberman discussing BFIT, Consumer health, mRNA cancer vaccines, GLP-1 drugs, HRTS, LLY, RETATRUTIDE, Sunosi, Sleep technology, Sleep tech, Real-time cortisol sensing, Continuous glucose monitors, Peptides, Non-GLP peptides, Magnesium supplements, AI healthcare diagnostics, Health information exchanges, Neurotech, Non-invasive neuromodulation, Longevity therapeutics, Plasma rejuvenation. 13 trade ideas extracted by AI with direction and confidence scoring.

Speakers: Daisy Wolf, Andrew Huberman  · Tickers: BFIT, Consumer health, mRNA cancer vaccines, GLP-1 drugs, HRTS, LLY, RETATRUTIDE, Sunosi, Sleep technology, Sleep tech, Real-time cortisol sensing, Continuous glucose monitors, Peptides, Non-GLP peptides, Magnesium supplements, AI healthcare diagnostics, Health information exchanges, Neurotech, Non-invasive neuromodulation, Longevity therapeutics, Plasma rejuvenation