Author holds and added to MREO, citing a cash runway into mid-2027 and the alvelestat pipeline after the setrusumab Phase 3 failures.
MREO — LONG The author holds and modestly added to MREO after the setrusumab Phase 3 miss, arguing the negative news is largely priced in at current levels. The mechanism is a remaining pipeline, especially alvelestat advancing toward a single global Phase 3 for AATD-associated lung disease, plus cash and equivalents of about $41 million as of Dec. 31, 2025 extending runway into mid-2027. The author notes the company is engaging regulators on next steps for setrusumab after positive bone mineral density data. Stated risks include regulatory hurdles, further trial setbacks, or dilution that could drive shares to zero.
That said, much of the negative news appears priced in at current levels, and there's still a viable pipeline (especially alvelestat) with a decent cash position to support operations.