Slippage

Has anyone worked on a strategy that uses slippage to your advantage? For example, I could see a scenario where different sized buy/sell orders could create different levels of slippage in more moderately traded assets. For example: Buy x 100 @ $10.00 ... Buy x 100 @ $10.00 Buy x 1,000 @ $10.25 Sell x 100 @ 10.25 Sell x 100 @ 10.25 ... Sell x 100 @ 10.25 How would you approach a strategy like this? Looking at order book for slippage opportunities?